Mobilized peripheral blood: an updated perspective
نویسندگان
چکیده
منابع مشابه
Quantity and quality of engrafting cells in cord blood and autologous mobilized peripheral blood.
Cord blood (CB) and autologous mobilized peripheral blood stem/progenitor cells (PBSC) are now used widely for clinical transplantation. We characterized the short-term (<8 weeks) and long-term (>8 weeks) engraftment in NOD/SCID mice resulting from transplanted CD34+ cells from these two sources. We also quantified the frequency of long-term engrafting cells, and the average proliferative capac...
متن کاملTransplantation of allogeneic peripheral blood stem cells mobilized by recombinant human granulocyte colony stimulating factor.
Recombinant G-CSF has been given to over 150 normal donors for the collection of allogeneic or syngeneic peripheral blood stem cells (PBSC). G-CSF was found to be well-tolerated with mild-moderate bone pain, edema and mild thrombocytopenia being the observed side effects. To date, approximately 90 unmodified primary PBSC transplants from HLA-identical related donors have been performed with eng...
متن کاملHEMATOPOIESIS CD99 expressed on human mobilized peripheral blood CD34 cells is involved in transendothelial migration
Hematopoietic progenitor cell trafficking is an important phenomenon throughout life. It is thought to occur in sequential steps, similar to what has been described for mature leukocytes. Molecular actors have been identified for each step of leukocyte migration; recently, CD99 was shown to play a part during transendothelial migration. We explored the expression and role of CD99 on human hemat...
متن کاملMobilized peripheral blood CD34+ cells express more amphotropic retrovirus receptor than bone marrow CD34+ cells.
BACKGROUND AND OBJECTIVE The increased susceptibility to gene transfer by amphotropic retroviral vectors of mobilized peripheral blood (PB) CD34+ cells compared to their bone marrow (BM) counterparts may depend, among other factors, on the level of expression of the amphotropic receptor on the progenitor cell. Using a previously described flow cytometry strategy, we have studied retrovirus bind...
متن کاملSenescent phenotypes and telomere lengths of peripheral blood T-cells mobilized by acute exercise in humans.
Acute bouts of aerobic exercise are known to mobilize antigen-experienced CD8+ T-cells expressing the cell surface marker of senescence, KLRG1, into the blood. It is not known; however if this is due to a selective mobilization of terminally differentiated T-cells (i.e., KLRG1 +/CD28-/CD57+) or a population of effector memory T-cells (i.e., KLRG1+/CD28+/CD57-) that have not reached terminal dif...
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ژورنال
عنوان ژورنال: F1000Research
سال: 2019
ISSN: 2046-1402
DOI: 10.12688/f1000research.21129.1